1: With tetrachloromethane; TEA; triphenylphosphine in chloroform T=80°C; 0.666667 h; 2: With TEA; water T=80°C; 12 h; 3: With hydrogenchloride in methanol 12 h; Heating;
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide T=20°C; 2: With hydrogenchloride in methanol; diethyl ether T=50°C; 0.5 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/127587 A1, 2006 ;
Location in patent: Page/Page column 103-104 ;
WO 2006/127587 A1
E. I. DU PONT DE NEMOURS AND COMPANY; HOLYOKE JR, Caleb, William; ZHANG, Wenming; TONG, My-Hanh, Thi
Patent: WO2011/17351 A2, 2011 ;
Location in patent: Page/Page column 29 ;
