反应条件
1: 88 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH2Cl2 / Ambient temperature
2: 100 percent / CF3COOH / CH2Cl2 / Ambient temperature
3: 100 percent / Et3N, diethoxyphosphoryl cyanide / CH2Cl2 / Ambient temperature
4: HCl (gas) / diethyl ether / 0.33 h / Ambient temperature
5: Et3N, diethylphosphoryl cyanide / CH2Cl2 / Ambient temperature
6: 5.81 g / CF3COOH / CH2Cl2 / Ambient temperature
7: 78 percent / Et3N, diethylphosphoryl cyanide / CH2Cl2 / Ambient temperature
8: 5.4 g / CF3COOH / CH2Cl2 / Ambient temperature
9: 97 percent / Et3N, diethoxyphosphoryl cyanide / CH2Cl2 / Ambient temperature
10: 85 percent / 1-hydroxybenzotriazole / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Thaisrivongs, Suvit; Pals, Donald T.; Harris, Douglas W.; Kati, Warren M.; Turner, Steve R.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2088 - 2093