6-(哌嗪-1-基)-4-氯嘧啶合成路线 (共 2 条)
反应条件
1: With N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C;
2: With trifluoroacetic acid in dichloromethane
T=20°C;
参考文献
GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus
Patent: US2013/137688 A1, 2013 ;
Location in patent: Paragraph 0247; 0248 ;
反应条件
potassium carbonate in acetonitrile
Heating;
参考文献
Ge, Hai-Xia; Wang, Li-Chen; Jiang, Zhen-Zhou; Ni, Sheng-Liang
Arzneimittel-Forschung/Drug Research, 2006 , vol. 56, # 10 p. 673 - 677