3-氟-4-羟基哌啶-1-甲酸叔丁酯合成路线 （共 3 条）
反应条件
1: With sodium tetrahydroborate in methanol T=0 - 20°C; 4.75 h; 2: With water; ammonium chloride in ethyl acetate
参考文献
WO2008/124323 A1, ;
Page/Page column 58 ;
WO 2008/124323 A1
反应条件
1: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) / acetonitrile / 2 h / 20 °C 2: sodium tetrahydroborate / 2 h / 20 °C View Scheme
参考文献
WO2012/68440 A1, ;
WO 2012/068440 A1
反应条件
1: triethylamine / N,N-dimethyl-formamide / 24 h / 80 °C 2: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) / acetonitrile / 2 h / 20 °C 3: sodium tetrahydroborate / 2 h / 20 °C View Scheme
参考文献
WO2012/68440 A1, ;
WO 2012/068440 A1
