N-boc-4-(环丙基甲基)哌嗪合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h;
参考文献
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co. Ltd.
Patent: EP2481739 A1, 2012 ;
Location in patent: Page/Page column 68 ;
反应条件
1: With sodium cyanoborohydride; acetic acid in tetrahydrofuran; water
T=20°C; 14 h;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Dorwald, Florencio Zaragoza; Andersen, Knud Erik; Sorensen, Jan Lindy
Patent: US2004/19039 A1, 2004 ;
Location in patent: Page/Page column 20 ;
US 20040019039 A1
反应条件
triethylamine in dichloromethane
12 h;
参考文献
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.
Patent: US2012/184543 A1, 2012 ;
Location in patent: Page/Page column 69 ;
反应条件
hydrogenchloride in methanol; dichloromethane
参考文献
PIRAMED LIMITED
Patent: WO2006/46031 A1, 2006 ;
Location in patent: Page/Page column 45-46 ;
WO 2006/046031 A1
