5-苯基-1,2,4-噁二唑-3-羧酸乙酯合成路线 （共 6 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine in dichloromethane T=-15 - 20°C; 2: With pyridine 20 h; RefluxSealed tube;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 193 ;
WO 2010/142801 A1
反应条件
1: K2CO3 / acetone 2: Heating View Scheme
参考文献
ChemoCentryx, Inc.; Fan, Junfa; Krasinski, Antoni; Lange, Christopher W.; Lui, Rebecca M.; McMahon, Jeffrey P.; Powers, Jay P.; Zeng, Yibin; Zhang, Penglie
Patent: US2014/154179 A1, 2014 ;
反应条件
1: NaOH / 0.5 h / Heating 2: 78 percent / aq. HCl, sodium nitrite View Scheme
参考文献
Kmetic; Stanovnik
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 5 p. 1563 - 1565
参考文献
Musante
Gazzetta Chimica Italiana, 1938 , vol. 68, p. 331,338
参考文献
Bast,K. et al.
Chemische Berichte, 1972 , vol. 105, p. 2825 - 2840
反应条件
lithium hydroxide hydrate in tetrahydrofuran; methanol; water
T=20°C; 3 h;
参考文献
ChemoCentryx, Inc.; Fan, Junfa; Krasinski, Antoni; Lange, Christopher W.; Lui, Rebecca M.; McMahon, Jeffrey P.; Powers, Jay P.; Zeng, Yibin; Zhang, Penglie
Patent: US2014/154179 A1, 2014 ;
Location in patent: Paragraph 0429; 0432 ;
