2-苯基-1H-吡咯并[3,2-c]吡啶合成路线 （共 13 条）
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 1,10-phenanthroline; carbon monoxide in acetonitrile
T=120°C; P=4560.31 Torr; 22 h;
参考文献
Gorugantula, Sobha P.; Carrero-Martinez, Grissell M.; Dantale, Shubhada W.; Soederberg, Bjoern C.G.
Tetrahedron, 2010 , vol. 66, # 10 p. 1800 - 1805
反应条件
sodium hydrogencarbonate in water
T=200°C; 1.5 h; Microwave irradiation;
参考文献
Carpita, Adriano; Ribecai, Arianna; Stabile, Paolo
Tetrahedron, 2010 , vol. 66, # 35 p. 7169 - 7178
反应条件
1: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in water; acetic acid; acetonitrile
T=0°C;
2: With iron; acetic acid in ethanol
Heating;
参考文献
Kuzmich, Daniel; Mulrooney, Carol
Synthesis, 2003 , # 11 p. 1671 - 1678
反应条件
1: acetophenone With allyl(1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene)palladium(IV) chloride; sodium hexamethyldisilazane in tetrahydrofuran
T=20°C; 0.0833333 h; Inert atmosphere;
2: 3-bromo-4-aminopyridine in tetrahydrofuran
T=20 - 100°C; 6 h; Inert atmosphere; regioselective reaction;
参考文献
Spergel, Steven H.; Okoro, Danielle R.; Pitts, William
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5316 - 5319
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in water; acetic acid; acetonitrile
T=0°C; Title compound not separated from byproducts;
参考文献
Kuzmich, Daniel; Mulrooney, Carol
Synthesis, 2003 , # 11 p. 1671 - 1678
反应条件
1.1: CH2Cl2
2.1: PCl3 / CH2Cl2
3.1: 97 percent / SnCl2*2H2O; NaOAc*3H2O / tetrahydrofuran; methanol / 0 °C
4.1: DDQ / acetonitrile; H2O; acetic acid / 0 °C
4.2: 60 percent / Fe; AcOH / ethanol / Heating
View Scheme
参考文献
Kuzmich, Daniel; Mulrooney, Carol
Synthesis, 2003 , # 11 p. 1671 - 1678
反应条件
1.1: CH2Cl2
2.1: PCl3 / CH2Cl2
3.1: 97 percent / SnCl2*2H2O; NaOAc*3H2O / tetrahydrofuran; methanol / 0 °C
4.1: DDQ / acetonitrile; H2O; acetic acid / 0 °C
4.2: 60 percent / Fe; AcOH / ethanol / Heating
View Scheme
参考文献
Kuzmich, Daniel; Mulrooney, Carol
Synthesis, 2003 , # 11 p. 1671 - 1678
反应条件
1.1: 97 percent / SnCl2*2H2O; NaOAc*3H2O / tetrahydrofuran; methanol / 0 °C
2.1: DDQ / acetonitrile; H2O; acetic acid / 0 °C
2.2: 60 percent / Fe; AcOH / ethanol / Heating
View Scheme
参考文献
Kuzmich, Daniel; Mulrooney, Carol
Synthesis, 2003 , # 11 p. 1671 - 1678
反应条件
1: 35 percent / glacial acetic acid / toluene / 30 h / Heating
2: 24 percent / K-16 / 560 - 580 °C
View Scheme
参考文献
Zvolinskii; Pleshakov; Prostakov
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 2 p. 202 - 205
反应条件
1: 35 percent / glacial acetic acid / toluene / 30 h / Heating
2: 24 percent / K-16 / 560 - 580 °C
View Scheme
参考文献
Zvolinskii; Pleshakov; Prostakov
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 2 p. 202 - 205
