1: With [Cu(N,N′-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene)Cl]; lithium methanolate in tetrahydrofuran T=70°C; P=760.051 Torr; 24 h; Inert atmosphere; 2: With hydrogenchloride in water Inert atmosphere;

cesium hydroxide; tris(dibenzylideneacetone)dipalladium (0); tri-cyclo-hexyl-phosphine in 1,4-dioxane T=90°C; Suzuki cross-coupling; 48 h;