21-羟基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯合成路线 （共 4 条）
参考文献
Schaub et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 4962,4966
反应条件
1.1: thionyl chloride / tetrahydrofuran / 0.67 h / 0 °C / |Inert atmosphere 1.2: 1.25 h / 5 - 20 °C 2.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0.5 h / 20 °C / |Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Hulcoop, David G.; Shapland, Peter D.P.
Steroids, 2013 , vol. 78, # 12-13 p. 1281 - 1287
反应条件
selenium(IV) oxide; tert-butyl alcohol
参考文献
Am.Cyanamid Co.
Patent: US2864834 , 1957 ;
反应条件
1.1: perchloric acid / water / 20 - 27 °C / |Inert atmosphere 1.2: 20 - 35 °C / |Inert atmosphere 2.1: potassium carbonate / water; acetone / 40 - 46 °C / |Inert atmosphere 3.1: copper dichloride / tetrahydrofuran / 0.02 h / 3 °C / |Inert atmosphere 3.2: 0.03 h / 3 °C / |Inert atmosphere 3.3: 1.75 h / 2.5 °C / |Inert atmosphere 4.1: peracetic acid; acetic acid / dichloromethane / 18 h / 4 - 20 °C / |Inert atmosphere View Scheme
参考文献
Hulcoop, David G.; Shapland, Peter D.P.
Steroids, 2013 , vol. 78, # 12-13 p. 1281 - 1287
