(S)-N-乙酰基-beta-萘基丙氨酸合成路线 （共 20 条）
反应条件
potassium chloride in dimethyl sulfoxide T=39°C; 10 h; subtilisin Carlsberg, pH 6.9;
参考文献
Rodriguez; Bernad; Galas; Lignon; Laur; Aumelas; Martinez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 3 p. 245 - 253
反应条件
acetic anhydride in sodium hydroxide
参考文献
Syntex Inc.
Patent: US4341767 A1, 1982 ;
反应条件
{Rh[ZhangPhos](nbd)}BF4; hydrogen in methanol T=20°C; P=1034.32 Torr; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Zhang, Xiaowei; Huang, Kexuan; Hou, Guohua; Cao, Bonan; Zhang, Xumu
Angewandte Chemie - International Edition, 2010 , vol. 49, # 36 p. 6421 - 6424
反应条件
sodium hydroxide; potassium chloride; sodium hydrogencarbonate in acetonitrile 5 h; Ambient temperaturesubtilisin, pH 7.8;
参考文献
Combret, Yves; Duflos, Jack; Dupas, Georges; Bourguignon, Jean; Queguiner, Guy
Tetrahedron: Asymmetry, 1993 , vol. 4, # 7 p. 1635 - 1644
反应条件
(microbiological transformation);
参考文献
Rodriguez; Bernad; Galas; Lignon; Laur; Aumelas; Martinez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 3 p. 245 - 253
反应条件
1: 1.) EtONa / 1.) EtOH, RT, 10 min, 2.) EtOH, reflux, 15 h 2: 88 percent / 3.9 M aq. NaOH / ethanol / 0.67 h / Ambient temperature 3: 81 percent / dioxane / 1 h / Heating 4: 48 percent / aq. KCl, NaHCO3, aq. NaOH / acetonitrile / 5 h / Ambient temperature; subtilisin, pH 7.8 View Scheme
参考文献
Berger,A. et al.
Journal of Organic Chemistry, 1973 , vol. 38, # 3 p. 457 - 460
反应条件
1: 81 percent / dioxane / 1 h / Heating 2: 48 percent / aq. KCl, NaHCO3, aq. NaOH / acetonitrile / 5 h / Ambient temperature; subtilisin, pH 7.8 View Scheme
参考文献
Rodriguez; Bernad; Galas; Lignon; Laur; Aumelas; Martinez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 3 p. 245 - 253
参考文献
Trivedi; Anson; Steel; Worley
Synlett, 2001 , # 12 p. 1932 - 1934
反应条件
cobalt(II) chloride T=30°C; pH=8; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Vaidya, Bhalchandra K.; Kuwar, Suyog S.; Golegaonkar, Sandeep B.; Nene, Sanjay N.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 74, # 3-4 p. 184 - 191
反应条件
1: 92 percent / 6 N aq. HCl / 2 h / Heating 2: 93 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
Rodriguez; Bernad; Galas; Lignon; Laur; Aumelas; Martinez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 3 p. 245 - 253
