2-溴-5-三氟甲基-1,3,4-噻唑合成路线 （共 5 条）
反应条件
after diazotization of 2-amino-5-trifluoromethyl-1,3,4-thiadiazole in modified Sandmeyer reaction;
参考文献
Gmelin Handbook: F: PerFHalOrg.SVol.2, 6.2.1.5.2, page 41 - 61
反应条件
thiourea in ethanol
T=80°C; 1 h;
参考文献
ACHAOGEN, INC.; MOSER, Heinz, E.; WAGMAN, Allan, S.
Patent: WO2010/123997 A1, 2010 ;
Location in patent: Page/Page column 64 ;
WO 2010/123997 A1
反应条件
potassium hydroxide in ethanol
refluxing in ethanol for 1 h, followed refluxing with aq.KOH for 20 min; acidifying the aqueous phase;
参考文献
Gmelin Handbook: F: PerFHalOrg.SVol.2, 6.2.1.5.2, page 41 - 61
反应条件
in benzene
Kinetics; in boiling benzene, 8 h;
参考文献
Gmelin Handbook: F: PerFHalOrg.SVol.2, 6.2.1.5.2, page 41 - 61
反应条件
triethylamine in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; Petroleum ether
参考文献
Bayer Aktiengesellschaft
Patent: US4097669 A1, 1978 ;
