3-溴-2-羟基-6-甲基吡啶合成路线 （共 4 条）
反应条件
1: With n-butyllithium T=-90°C; 2: With water T=-90°C;
参考文献
Meana, Angela; Rodriguez, Justo F.; Sanz-Tejedor, M. Ascension; Garcia-Ruano, Jose L.
Synlett, 2003 , # 11 p. 1678 - 1682
反应条件
1.1: 89 percent / NBS / acetonitrile / 1 h / Heating 2.1: n-BuLi / -90 °C 2.2: 80 percent / H2O / -90 °C View Scheme
参考文献
Meana, Angela; Rodriguez, Justo F.; Sanz-Tejedor, M. Ascension; Garcia-Ruano, Jose L.
Synlett, 2003 , # 11 p. 1678 - 1682
反应条件
N-bromosuccinmide in acetonitrile Title compound not separated from byproducts;
参考文献
Meana, Angela; Rodriguez, Justo F.; Sanz-Tejedor, M. Ascension; Garcia-Ruano, Jose L.
Synlett, 2003 , # 11 p. 1678 - 1682
反应条件
1: With nitric acid in water
T=0 - 20°C; 3.5 h;
2: With sodium hydroxide in water; ethyl acetate
pH=4;
参考文献
SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED
Patent: WO2008/101682 A2, 2008 ;
Location in patent: Page/Page column 42 ;
