5,8-二甲氧基-3,4-二氢-1H-2-萘酮合成路线 （共 40 条）
反应条件
1: 90 percent / t-butyl hydroperoxide / VO(acac)2 / 4 h / Ambient temperature 2: 83 percent / LAH / tetrahydrofuran / 4 h / Ambient temperature 3: pyridinium dichromate / or PCC View Scheme
参考文献
Mehendale, A. R.; Kulkarni, Alpana; Nagarajan, Geeta
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. <B> 27, # 1-12 p. 305 - 307
反应条件
1: ethanol; charcoal 2: aq.-ethanolic HCl View Scheme
参考文献
Lewis et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 5321,5322
反应条件
1: ethanolic sodium ethylate / anschliessend mit CH3I 2: ethanol; charcoal 3: aq.-ethanolic HCl View Scheme
参考文献
Lewis et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 5321,5322
反应条件
Collins oxidation agent in dichloromethane 0.75 h; Ambient temperature;
参考文献
Tanno; Terashima
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 811 - 820
反应条件
1: NaBH4 / ethanol / 12 h / Ambient temperature 2: p-toluenesulfonic acid monohydrate / benzene / 0.5 h / Heating 3: m-chloroperbenzoic acid / CH2Cl2 / 12 h / 0 °C 4: p-toluenesulfonic acid monohydrate / toluene / 1.5 h / Heating View Scheme
参考文献
Perez; Rosell; Mauleon; Carganico
Farmaco, 1991 , vol. 46, # 10 p. 1155 - 1166
反应条件
1: m-chloroperbenzoic acid / CH2Cl2 / 12 h / 0 °C 2: p-toluenesulfonic acid monohydrate / toluene / 1.5 h / Heating View Scheme
参考文献
Perez; Rosell; Mauleon; Carganico
Farmaco, 1991 , vol. 46, # 10 p. 1155 - 1166
反应条件
1: p-toluenesulfonic acid monohydrate / benzene / 0.5 h / Heating 2: m-chloroperbenzoic acid / CH2Cl2 / 12 h / 0 °C 3: p-toluenesulfonic acid monohydrate / toluene / 1.5 h / Heating View Scheme
参考文献
Perez; Rosell; Mauleon; Carganico
Farmaco, 1991 , vol. 46, # 10 p. 1155 - 1166
反应条件
hydrogenchloride; potassium carbonate in acetone Heating; Yield given;
参考文献
Rao, Rama A. V.; Deshpande, V. H.; Reddy, Laxma N.
Tetrahedron Letters, 1980 , vol. 21, p. 2661 - 2664
反应条件
1: 91 percent / m-CPBA / CH2Cl2 / 12 h / 20 °C 2: 42 percent / MgBr2*Et2O / toluene / 6 h / Heating View Scheme
参考文献
Tririya, Gasirat; Zanger, Murray
Synthetic Communications, 2004 , vol. 34, # 17 p. 3047 - 3059
反应条件
1: 91 percent / AcOH; aq. HBr / 0.25 h / 110 - 115 °C 2: 68 percent / NaOH / H2O / 12 h / 20 °C 3: 91 percent / m-CPBA / CH2Cl2 / 12 h / 20 °C 4: 42 percent / MgBr2*Et2O / toluene / 6 h / Heating View Scheme
参考文献
Tririya, Gasirat; Zanger, Murray
Synthetic Communications, 2004 , vol. 34, # 17 p. 3047 - 3059
