1-(2-羟基乙基)-3-苯基脲合成路线 （共 14 条）
反应条件
tetrachloromethane; triethylamine; triphenylphosphine in pyridine; acetonitrile T=2°C; 20 h;
参考文献
Vorbruggen; Krolikiewicz
Tetrahedron, 1993 , vol. 49, # 41 p. 9353 - 9372
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu reaction; 0.583333 h;
参考文献
Kim, Taek Hyeon; Lee, Gue-Jae; Cha, Mi-Hyun
Synthetic Communications, 1999 , vol. 29, # 16 p. 2753 - 2758
反应条件
potassium tert-butylate; p-toluenesulfonyl chloride in tetrahydrofuran T=0 - 5°C; 0.166667 h;
参考文献
Kim, Taek Hyeon; Lee, Gue-Jae
Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2941 - 2943
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu reaction; 0.583333 h;
参考文献
Synthetic Communications, , vol. 29, # 16 p. 2753 - 2758
参考文献
Leonov; Shcherbakov; Devichensky; Kryukova; Vorontsov; Kuznetsov; Kryukov
Russian Journal of Bioorganic Chemistry, 2001 , vol. 27, # 3 p. 191 - 194
反应条件
1: benzoyl hydroxylamine With ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate; N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=0°C; Lossen Rearrangement; 1.5 h;
2: ethanolamine in tetrahydrofuran
T=20°C; Lossen Rearrangement; 4 h;
参考文献
Thalluri, Kishore; Manne, Srinivasa Rao; Dev, Dharm; Mandal, Bhubaneswar
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3765 - 3775
反应条件
KIO3; sodium hydroxide
参考文献
Capps; Dehn
Journal of the American Chemical Society, 1932 , vol. 54, p. 4301,4302
反应条件
1: pyridine / dichloromethane / 4 h / 20 °C
2: ethanol / 7 h / |Reflux
View Scheme
参考文献
Luo, Wei; Xia, Ming-Yu; Ikejima, Takashi; Li, Li-Hua; Guo, Chun
Medicinal Chemistry Research, 2013 , vol. 22, # 7 p. 3170 - 3176
反应条件
1.1: N-ethyl-N,N-diisopropylamine; ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 0.5 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate / tetrahydrofuran / 1.5 h / 0 °C
2.2: 4 h / 20 °C
View Scheme
参考文献
Thalluri, Kishore; Manne, Srinivasa Rao; Dev, Dharm; Mandal, Bhubaneswar
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3765 - 3775
反应条件
2-(2-Ethoxyethoxy)ethyl benzyl ether in benzyl alcohol
参考文献
Loecsei, Vasile; Facsko, Otilia; Chirila, Traian
Journal fuer Praktische Chemie (Leipzig), 1982 , vol. 324, # 5 p. 816 - 826
