3-羟基-1-噁-9-氮杂螺[5.5]十一烷-9-羧酸 1,1-二甲基乙酯合成路线 （共 2 条）
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 0 - 23 °C
2.1: RuCl2(tricyclohexylphosphine)2(benzylidene) / dichloromethane / 18 h / 0 - 23 °C
3.1: borane-THF / tetrahydrofuran / 18 h / 0 °C
3.2: 1 h / 0 - 23 °C
View Scheme
参考文献
Cernak, Timothy; Dykstra, Kevin; Levorse, Dorothy; Verras, Andreas; Balkovec, James; Nargund, Ravi; DeVita, Robert
Tetrahedron Letters, 2011 , vol. 52, # 48 p. 6457 - 6459
反应条件
1.1: tetrahydrofuran; diethyl ether / 18 h / 0 - 23 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 0 - 23 °C
3.1: RuCl2(tricyclohexylphosphine)2(benzylidene) / dichloromethane / 18 h / 0 - 23 °C
4.1: borane-THF / tetrahydrofuran / 18 h / 0 °C
4.2: 1 h / 0 - 23 °C
View Scheme
参考文献
Cernak, Timothy; Dykstra, Kevin; Levorse, Dorothy; Verras, Andreas; Balkovec, James; Nargund, Ravi; DeVita, Robert
Tetrahedron Letters, 2011 , vol. 52, # 48 p. 6457 - 6459
