2,4-二羟基-6-甲基吡啶合成路线 （共 34 条）
参考文献
Rivalle; Bisagni
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 2 p. 245 - 248
反应条件
1: 1 h / 140 °C
2: K2CO3 / H2O / 0.5 h / 100 °C
View Scheme
参考文献
Stoyanov, Edmont V.; Ivanov, Ivo C.
Synthetic Communications, 1998 , vol. 28, # 10 p. 1755 - 1767
反应条件
phosphorus tribromide
T=190°C;
参考文献
Taisho Pharmaceutical Co. Ltd.; Nissan Chemical Industries, Ltd.
Patent: EP2003131 A1, 2008 ;
Location in patent: Page/Page column 60 ;
EP 2003131 A1
反应条件
1: phosphorus (III)-bromide / 190 °C
2: aqueous NH3 / 205 °C
View Scheme
参考文献
Bernstein et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 1147,1148
参考文献
Stoyanov, Edmont V.; Ivanov, Ivo C.
Synthetic Communications, 1998 , vol. 28, # 10 p. 1755 - 1767
反应条件
aluminium trichloride
T=180°C; 1 h;
参考文献
Kappe,T. et al.
Monatshefte fuer Chemie, 1971 , vol. 102, # 5 p. 1392 - 1399
反应条件
in nitrobenzene
T=200°C; 0.75 h;
参考文献
Kappe,T. et al.
Monatshefte fuer Chemie, 1971 , vol. 102, # 5 p. 1392 - 1399
参考文献
Mueller,A.K. et al.
Justus Liebigs Annalen der Chemie, 1976 , p. 400 - 406
参考文献
Rivalle; Bisagni
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 2 p. 245 - 248
反应条件
sodium; methyl 4-toluenesulfonate
Reflux, 20 h; Yield given. Multistep reaction;
参考文献
Beak, Peter; Covington, Johnny B.; Smith, Stanley G.; White, J. Matthew; Zeigler, John M.
Journal of Organic Chemistry, 1980 , vol. 45, # 8 p. 1354 - 1362
