1-甲基-2-吲哚甲酸甲酯合成路线 （共 19 条）
反应条件
potassium carbonate in N-methyl-acetamide
参考文献
Sankyo Company, Limited
Patent: US5624935 A1, 1997 ;
反应条件
1: 96 percent / H2SO4 / 23 h / Heating
2: NaH / tetrahydrofuran / 15.5 h / 0 °C
View Scheme
参考文献
Ganton, Michael D.; Kerr, Michael A.
Organic Letters, 2005 , vol. 7, # 21 p. 4777 - 4779
参考文献
Johnson et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 423,428
Journal of the American Chemical Society, 1947 , vol. 69, p. 2370
反应条件
1.1: 67 percent / xylene / 0.25 h / Heating
2.1: KOH / dimethylsulfoxide / 20 °C
2.2: 93 percent / dimethylsulfoxide / 20 °C
View Scheme
参考文献
Sechi, Mario; Derudas, Massimiliano; Dallocchio, Roberto; Dessi, Alessandro; Bacchi, Alessia; Sannia, Luciano; Carta, Fabrizio; Palomba, Michele; Ragab, Omar; Chan, Carney; Shoemaker, Robert; Sei, Shizuko; Dayam, Raveendra; Neamati, Nouri
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5298 - 5310
反应条件
1.1: 52 percent / MeONa / methanol / 4 h / -15 °C
2.1: 67 percent / xylene / 0.25 h / Heating
3.1: KOH / dimethylsulfoxide / 20 °C
3.2: 93 percent / dimethylsulfoxide / 20 °C
View Scheme
参考文献
Sechi, Mario; Derudas, Massimiliano; Dallocchio, Roberto; Dessi, Alessandro; Bacchi, Alessia; Sannia, Luciano; Carta, Fabrizio; Palomba, Michele; Ragab, Omar; Chan, Carney; Shoemaker, Robert; Sei, Shizuko; Dayam, Raveendra; Neamati, Nouri
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5298 - 5310
反应条件
1: 1H-Indole-2-carboxylic acid methyl ester With sodium hydride in N,N-dimethyl-formamide
T=0°C; Inert atmosphere;
2: Me-X in N,N-dimethyl-formamide
T=0 - 20°C; Inert atmosphere;
参考文献
Praveen, Chandrasekaran; Perumal, Paramasivan Thirumalai
Synlett, 2011 , # 4 p. 521 - 524
反应条件
1.1: LiAlH4 / tetrahydrofuran / 0 - 20 °C
2.1: NaH / tetrahydrofuran / 0.5 h / 0 - 20 °C
2.2: 327 mg / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Agnusdei, Marianna; Bandini, Marco; Melloni, Alfonso; Umani-Ronchi, Achille
Journal of Organic Chemistry, 2003 , vol. 68, # 18 p. 7126 - 7129
参考文献
Johnson et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 423,428
Journal of the American Chemical Society, 1947 , vol. 69, p. 2370
反应条件
1: 1.96 g / KOH; H2O / methanol / 16 h / Heating
2: SOCl2 / dioxane / 6 h / Heating
3: 0.910 g / NH3 / dioxane / 14 h
View Scheme
参考文献
Ganton, Michael D.; Kerr, Michael A.
Organic Letters, 2005 , vol. 7, # 21 p. 4777 - 4779
