(R)-2-羟基-2-甲基丁酸合成路线 （共 12 条）
反应条件
sodium hydroxide in methanol
T=60°C; 4 h;
参考文献
Chang, Jia-Wen; Jang, Der-Pin; Uang, Biing-Jiun; Liao, Fen-Ling; Wang, Sue-Lein
Organic Letters, 1999 , vol. 1, # 13 p. 2061 - 2063
反应条件
potassium hydroxide
11 h; Heating;
参考文献
Crout, David H. G.; McIntyre, C. Rupert; Alcock, Nathaniel W.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 1 p. 53 - 62
反应条件
1: HgO, CF3CO2H, BF3-Et2O
2: (i) TsOH, aq. dioxane, (ii) NaOBr
View Scheme
参考文献
Faulkner; Petersen
Journal of the American Chemical Society, 1973 , vol. 95, # 2 p. 553 - 563
反应条件
(i) NBS, DMF, (ii) nBu3SnH, benzene, (iii) aq. HCl; Multistep reaction;
参考文献
Terashima,S.; Jew,S.
Tetrahedron Letters, 1977 , p. 1005 - 1008
反应条件
1: 78 percent / tri-n-butyltin hydride / benzene / 15 h / Heating
2: 98 percent / aqueous KOH / 11 h / Heating
View Scheme
参考文献
Crout, David H. G.; McIntyre, C. Rupert; Alcock, Nathaniel W.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 1 p. 53 - 62
反应条件
hydrogenchloride; water
T=60 - 70°C; 20 h; optical yield given as percent ee;
参考文献
Cabirol, Fabien L.; Pei, Loo Tan; Tay, Benson; Cheng, Shiryn; Hanefeld, Ulf; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 14-15 p. 2329 - 2338
反应条件
(i) TsOH, aq. dioxane, (ii) NaOBr; Multistep reaction;
参考文献
Faulkner; Petersen
Journal of the American Chemical Society, 1973 , vol. 95, # 2 p. 553 - 563
反应条件
hydrogenchloride
8 h; Heating;
参考文献
Ludwig, Jerry W.; Newcomb, Martin; Bergbreiter, David E.
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2731 - 2734
反应条件
hydrogenchloride
8 h; Heating;
参考文献
Ludwig, Jerry W.; Newcomb, Martin; Bergbreiter, David E.
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2731 - 2734
反应条件
hydrogenchloride
1) (R)-oxynitrilase, Avicel cellulose, 0.02 M sodium acetate buffer, diisopropylether, 0 deg C, 41h, 2) a) r.t., 16h, b) reflux, 5h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Effenberger; Horsch; Weingart; Ziegler; Kuhner
Tetrahedron Letters, 1991 , vol. 32, # 23 p. 2605 - 2608
