(S)-2-羟基-2-甲基丁酸合成路线 （共 15 条）
反应条件
sulfuric acid Heating;
参考文献
Elan Pharmaceuticals, Inc.; ELI LILLY AND COMPANY
Patent: EP951464 B1, 2005 ;
Location in patent: Page/Page column 44; 30 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol
Ambient temperature;
参考文献
Sugai, Takeshi; Kakeya, Hideaki; Ohta, Hiromichi
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4643 - 4647
反应条件
hydrogen; nickel
T=75°C; 2 h;
参考文献
Fechter, Martin H.; Gruber, Karl; Avi, Manuela; Skranc, Wolfgang; Schuster, Christian; Poechlauer, Peter; Klepp, Kurt O.; Griengl, Herfried
Chemistry - A European Journal, 2007 , vol. 13, # 12 p. 3369 - 3376
反应条件
1: 54 percent / various solvent(s) / 96 h / 30 °C / lipase OF
2: 67 percent / H2 / 10percent Pd-C / ethanol / Ambient temperature
View Scheme
参考文献
Sugai, Takeshi; Kakeya, Hideaki; Ohta, Hiromichi
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4643 - 4647
反应条件
hydrogenchloride; water
T=60 - 70°C; 20 h; optical yield given as percent ee;
参考文献
Cabirol, Fabien L.; Pei, Loo Tan; Tay, Benson; Cheng, Shiryn; Hanefeld, Ulf; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 14-15 p. 2329 - 2338
反应条件
1: 65 percent / conc. HCl; H2O / 16 h / 85 °C
2: 82 percent / H2; aq. NaON / Raney nickel / 2 h / 75 °C
View Scheme
参考文献
Fechter, Martin H.; Gruber, Karl; Avi, Manuela; Skranc, Wolfgang; Schuster, Christian; Poechlauer, Peter; Klepp, Kurt O.; Griengl, Herfried
Chemistry - A European Journal, 2007 , vol. 13, # 12 p. 3369 - 3376
反应条件
hydrogenchloride
8 h; Heating;
参考文献
Ludwig, Jerry W.; Newcomb, Martin; Bergbreiter, David E.
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2731 - 2734
反应条件
hydrogenchloride
8 h; Heating;
参考文献
Ludwig, Jerry W.; Newcomb, Martin; Bergbreiter, David E.
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2731 - 2734
反应条件
hydrogenchloride
12 h; Heating;
参考文献
Cardillo, Giuliana; Hashem, Md. Abul; Tomasini, Claudia
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 5 p. 1487 - 1488
反应条件
hydrogenchloride
1) (R)-oxynitrilase, Avicel cellulose, 0.02 M sodium acetate buffer, diisopropylether, 0 deg C, 41h, 2) a) r.t., 16h, b) reflux, 5h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Effenberger; Horsch; Weingart; Ziegler; Kuhner
Tetrahedron Letters, 1991 , vol. 32, # 23 p. 2605 - 2608
