(S)-2-羟基-2-甲基丁酸合成路线 （共 15 条）
反应条件
1: 1) MeMgCl / 1) THF, 1 h, 0 deg C, 2) 40 deg C, 8 h
2: 1) Hg(OCOCF3)2, 2) 2M NaOH, 0.5M NaBH4 / 1) CH2Cl2, rt, 1 h, 2) 0 deg C, 30 min
3: 11M HCl / 12 h / Heating
View Scheme
参考文献
Cardillo, Giuliana; Hashem, Md. Abul; Tomasini, Claudia
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 5 p. 1487 - 1488
反应条件
1: 1) Hg(OCOCF3)2, 2) 2M NaOH, 0.5M NaBH4 / 1) CH2Cl2, rt, 1 h, 2) 0 deg C, 30 min
2: 11M HCl / 12 h / Heating
View Scheme
参考文献
Cardillo, Giuliana; Hashem, Md. Abul; Tomasini, Claudia
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 5 p. 1487 - 1488
反应条件
Gewinnung ueber das Brucin-Salz;
参考文献
Mattocks,A.R.
Journal of the Chemical Society, 1964 , p. 1918 - 1930
参考文献
Fried et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 4621,4627
Journal of the American Chemical Society, 1952 , vol. 74, p. 3041,3044
Full Text Show Details
Poethke
Archiv der Pharmazie (Weinheim, Germany), 1937 , vol. 275, p. 357,367, 571, 586
反应条件
potassium carbonate in acetonitrile
T=20°C; 36 h;
参考文献
Ikegai, Kazuhiro; Pluempanupat, Wanchai; Mukaiyama, Teruaki
Bulletin of the Chemical Society of Japan, 2006 , vol. 79, # 5 p. 780 - 790
