hydrogen bromide in acetonitrile T=20°C; 1 h;

1: 3,3-bis(ethylthio)-1-phenylprop-2-en-1-one; 3,4,5-trimethoxyphenylboronic acid With tetrakis(triphenylphosphine) palladium(0); caesium carbonate in tetrahydrofuran T=50°C; Liebeskind-Srogl coupling; 2 h; Inert atmosphere; 2: phenylhydrazine With potassium tert-butylate in tert-butyl alcohol 12 h; Reflux; regioselective reaction;

tetrakis(triphenylphosphine) palladium(0); copper(I) thiophene-2-carboxylate; potassium carbonate; 1,2-bis-(diphenylphosphino)ethane in tetrahydrofuran T=50°C; Liebeskind-Srogl cross-coupling; 13 h; Inert atmosphere;