1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 30 min, 2.) room temp., 3 h 2: 64 percent / CrO3/pyridine / CH2Cl2 / 0.75 h / Ambient temperature 3: 65 percent / K2CO3, 18-crown-6 / toluene / 6 h / 75 °C 4: 100 percent / 97percent HCOOH, triethylamine / 5percent Pd/C / toluene / 0.5 h / 85 °C 5: 1.) NaH, Me2SO / 1.) 17 deg C, 30 min, 2.) 40 deg C, 46 h 6: 75 percent / glacial acetic acid/water / tetrahydrofuran / 3 h / 45 °C View Scheme