1,4-双(氯甲基)-2,5-二甲氧基苯合成路线 （共 18 条）
反应条件
1: With thiourea in acetone
4 h; Heating;
2: With sodium hydroxide
T=80°C; 7 h; Further stages.;
参考文献
Cangelosi, Virginia M.; Zakharov, Lev N.; Fontenot, Sean A.; Pitt, Melanie A.; Johnson, Darren W.
Dalton Transactions, 2008 , # 26 p. 3447 - 3453
反应条件
1: dimethylsulfoxide
3: SOCl2 / diethyl ether
View Scheme
参考文献
Sakamoto,K.; Oki,M.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 497 - 504
反应条件
1-ethoxyethanol; acetone
参考文献
Wood; Gibson
Journal of the American Chemical Society, 1949 , vol. 71, p. 393
反应条件
in dimethyl sulfoxide
参考文献
Fabre, Jean-Marc; Torreilles, Eliane; Vigroux, Michel; Ciral, Louis
Journal of Chemical Research, Miniprint, 1980 , # 11 p. 4572 - 4592
反应条件
1: dimethylsulfoxide
View Scheme
参考文献
Sakamoto,K.; Oki,M.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 497 - 504
反应条件
1: 95 percent / glacial acetic acid / Heating
2: 94 percent / NaOH, H20 / tetrahydrofuran; methanol / Heating
View Scheme
参考文献
Witiak; Loper; Ananthan; Almerico; Verhoef; Filppi
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1636 - 1642
反应条件
acetic acid
Heating;
参考文献
Witiak; Loper; Ananthan; Almerico; Verhoef; Filppi
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1636 - 1642
反应条件
(i) nBu2NH, (ii) /BRN= 385737/; Multistep reaction;
参考文献
Schill,G.; Tafelmair,L.
Justus Liebigs Annalen der Chemie, 1973 , p. 2055 - 2070
