2-氯-2-[2-(2-硝基苯基)亚肼基]乙酸乙酯合成路线 （共 7 条）
反应条件
hydrogenchloride; sodium nitrite in methanol
T=20°C;
参考文献
Catarzi, Daniela; Colotta, Vittoria; Varano, Flavia; Lenzi, Ombretta; Filacchioni, Guido; Trincavelli, Letizia; Martini, Claudia; Montopoli, Christian; Moro, Stefano
Journal of Medicinal Chemistry, 2005 , vol. 48, # 25 p. 7932 - 7945
反应条件
hydrogenchloride; sodium acetate; sodium nitrite
1.) water; 2.) water, ethanol, 0 - 5 deg C, 3 h -> overnight; Multistep reaction;
参考文献
Bernard; Cocco; Maccioni; Plumitallo
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 4 p. 259 - 271
参考文献
Huisgen; Koch
Justus Liebigs Annalen der Chemie, 1955 , vol. 591, p. 200,221
参考文献
Fusco; Rossi
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 484,493
Rend.Ist.lomb., 1957 , vol. 91, p. 186,199
反应条件
1: NH3
2: iron; aqueous HCl; acetic acid
3: NaNO2; aqueous HCl; acetic acid
4: N2H4+H2O
5: aqueous HCl; NaNO2
7: aqueous HCl
View Scheme
参考文献
Fusco; Rossi
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 484,493
Rend.Ist.lomb., 1957 , vol. 91, p. 186,199
反应条件
1: NH3
2: iron; aqueous HCl; acetic acid
3: NaNO2; aqueous HCl; acetic acid
4: aq. NaOH solution
5: copper / unter vermindertem Druck
View Scheme
参考文献
Fusco; Rossi
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 484,493
Rend.Ist.lomb., 1957 , vol. 91, p. 186,199
反应条件
1: NH3
2: iron; aqueous HCl; acetic acid
3: NaNO2; aqueous HCl; acetic acid
4: aq. NaOH solution
View Scheme
参考文献
Fusco; Rossi
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 484,493
Rend.Ist.lomb., 1957 , vol. 91, p. 186,199
