2,3-二氢-2-硫代氧基-4-苯并噻唑羧酸合成路线 （共 4 条）
反应条件
1: 3-chloro-2-nitro-benzoic acid With Na2S*9H2O; sulfur; sodium hydroxide in water
6 h; Reflux;
2: carbon disulfide in water
T=45°C; 20 h;
3: With acetic acid in water
Cooling with ice;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.
Patent: WO2010/19606 A1, 2010 ;
Location in patent: Page/Page column 84-85 ;
WO 2010/019606 A1
参考文献
Merck and Co., Inc.
Patent: US5498777 A1, 1996 ;
参考文献
Merck and Co., Inc.
Patent: US5538964 A1, 1996 ;
反应条件
phosphorus pentachloride; trichlorophosphate in N,N-dimethyl-formamide
3 h; Reflux;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.
Patent: WO2010/19606 A1, 2010 ;
Location in patent: Page/Page column 85-86 ;
WO 2010/019606 A1
