5-溴-2-氟-6-甲基吡啶合成路线 (共 3 条)
反应条件
pyridine hydrogenfluoride; sodium nitrite
参考文献
Liu, Luping; Stelmach, John E.; Natarajan, Swaminathan R.; Chen, Meng-Hsin; Singh, Suresh B.; Schwartz, Cheryl D.; Fitzgerald, Catherine E.; O'Keefe, Stephen J.; Zaller, Dennis M.; Schmatz, Dennis M.; Doherty, James B.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3979 - 3982
反应条件
in dimethyl sulfoxide T=100°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BENDELS, Stefanie; GRETHER, Uwe; KIMBARA, Atsushi; NETTEKOVEN, Matthias; ROEVER, Stephan; ROGERS-EVANS, Mark; SCHAFFTER, Ernst; SCHULZ-GASCH, Tanja
Patent: WO2014/86806 A1, 2014 ;
Location in patent: Page/Page column 49 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
T=80°C; 1 h; Irradiation;
参考文献
Liu, Luping; Stelmach, John E.; Natarajan, Swaminathan R.; Chen, Meng-Hsin; Singh, Suresh B.; Schwartz, Cheryl D.; Fitzgerald, Catherine E.; O'Keefe, Stephen J.; Zaller, Dennis M.; Schmatz, Dennis M.; Doherty, James B.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3979 - 3982