5-氯-N,2-二羟基苯甲酰胺合成路线 （共 5 条）
反应条件
1: HCl / acetic acid 2: aq. NaOH View Scheme
参考文献
Reisner; Ludwig; Stiefel; Gister; Meyer; Powell; Sofia
Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 760 - 766
反应条件
1: carbonyldiimidazole / tetrahydrofuran / Heating 2: POCl3, Et3N / Heating View Scheme
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
反应条件
thionyl chloride in pyridine; diethyl ether
参考文献
Friary,R.; Sunday,B.R.
Journal of Heterocyclic Chemistry, 1979 , vol. 16, p. 1277 - 1278
反应条件
sodium hydroxide; sulfuric acid; hydroxylammonium sulfate in methanol; water
参考文献
Carter-Wallace, Inc.
Patent: US4224443 A1, 1980 ;
反应条件
ethanol; hydroxylamine
参考文献
Buu-Hoi et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1953 , vol. 236, p. 635
