Boc-N-甲基-L-苯丙氨酸合成路线 （共 22 条）
反应条件
1: NaHCO3 / 2-methyl-propan-2-ol 2: NaH / tetrahydrofuran View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 40 p. 7373 - 7376
反应条件
1: ClCOOiBu, NMM / 1,2-dimethoxy-ethane 2: 1.) BuLi, HMPT / 1.) THF, -78 deg C, 5 min, 2.) THF, RT, overnight 3: LiOH, LiBr, Bu4NBr / acetonitrile / 1 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 11 p. 1369 - 1374
反应条件
1: 1.) BuLi, HMPT / 1.) THF, -78 deg C, 5 min, 2.) THF, RT, overnight 2: LiOH, LiBr, Bu4NBr / acetonitrile / 1 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 11 p. 1369 - 1374
反应条件
1: triethylamine / dioxane; H2O / 4 h / Ambient temperature 2: NaH / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 47, # 29 p. 5453 - 5462
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.03 h / 0 °C 1.2: 2 h / 20 °C 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 0 - 20 °C View Scheme
参考文献
Asian Journal of Chemistry, , vol. 24, # 1 p. 319 - 322
反应条件
1.1: sodium carbonate / water; ethyl acetate / 0 - 16 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.03 h / 0 °C 2.2: 2 h / 20 °C 3.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 0 - 20 °C View Scheme
参考文献
Asian Journal of Chemistry, , vol. 24, # 1 p. 319 - 322
反应条件
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 119, # 4 p. 656 - 673
反应条件
hydrogenchloride in water T=110°C; 2 h;
参考文献
Imae, Yasufumi; Takada, Kentaro; Okada, Shigeru; Ise, Yuji; Yoshimura, Hiroshi; Morii, Yasuhiro; Matsunaga, Shigeki
Journal of Natural Products, 2013 , vol. 76, # 4 p. 755 - 758
反应条件
hydrogenchloride T=110°C;
参考文献
Imae, Yasufumi; Takada, Kentaro; Okada, Shigeru; Ise, Yuji; Yoshimura, Hiroshi; Morii, Yasuhiro; Matsunaga, Shigeki
Journal of Natural Products, 2013 , vol. 76, # 4 p. 755 - 758
反应条件
thionyl chloride T=0 - 20°C; 3 h;
参考文献
Mollica, Adriano; Costante, Roberto; Stefanucci, Azzurra; Pinnen, Francesco; Luisi, Grazia; Pieretti, Stefano; Borsodi, Anna; Bojnik, Engin; Benyhe, Sandor
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 167 - 177
