2: 1.) 5N HCl, 2.) isoamyl nitrite, 3.) DIEA 3: H2 / 10percent Pd/C / ethanol; acetic acid / 760 Torr / Ambient temperature View Scheme

1: 1.) 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride / 1.) CH2Cl2, 15 min, 2.) CH2Cl2, MeOH, overnight 2: 89 percent / TFA / CH2Cl2 / 1 h 3: 1.) 1-hydroxy-7-azabenzotriazole, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 2.) diisopropylethylamine / 1.) CH2Cl2, DMF, 15 min, 2.) CH2Cl2, DMF, overnight 4: 87 percent / TFA / CH2Cl2 / 0.17 h 5: 1.) 1-hydroxy-7-azabenzotriazole, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 2.) diisopropylethylamine / 1.) CH2Cl2, DMF, 15 min, 2.) CH2Cl2, DMF, overnight 6: 41 percent / TFA / CH2Cl2 / 0.12 h View Scheme