1: With cesium fluoride in toluene; acetonitrile T=110°C; 48 h; Inert atmosphereSealed vial; 2: With trifluoroacetic acid T=20°C; 0.333333 h;

1.1: cesium fluoride / toluene; acetonitrile / 48 h / 110 °C / Inert atmosphere; Sealed vial 1.2: 0.33 h / 20 °C 2.1: pyridine / dichloromethane / 2 h / 20 °C 3.1: Oxonereg;; palladium diacetate; toluene-4-sulfonic acid; 2,2,2-trimethylacetic acid / N,N-dimethyl-formamide / 12 h / 20 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran; toluene / 4 h / 100 °C View Scheme

zinc(II) chloride T=190°C;

T=190°C;