4-(4-甲基苯氧基)苯甲腈合成路线 （共 12 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2: With water; sodium hydroxide in tetrahydrofuran T=20°C;
参考文献
EP2248423 A1, ;
Page/Page column 264-265 ;
反应条件
1.1: potassium hydroxide; dihydrogen peroxide / methanol; ethanol / |Reflux
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 24 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui
European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 523 - 534
