2-氨基-5-溴-1,3,4-噻二唑合成路线 （共 13 条）
反应条件
bromine; sodium hydrogencarbonate in methanol T=20°C;
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO)
Patent: WO2009/40552 A2, 2009 ;
Location in patent: Page/Page column 50-51 ;
WO 2009/040552 A2
反应条件
1: With sulfuric acid in water 3 h; Reflux; 2: With ammonium hydroxide; bromine in water pH=3.5 - 8; 3: in water
参考文献
URIFER LTD.; NIR, Uri; SHPUNGIN, Sally; YAFFE, Etai; COHEN, Moshe
Patent: WO2010/97798 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
bromine in ethanol; water; acetic acid
反应条件
in water 44 h; Reflux;
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; KURZ, Guido; RICO FERREIRA, Maria del Rosario; SOILAN RODRIGUEZ, David; ORTEGA SORET, Miguel Angel; LINK, Wolfang; RABAL GRACIA, Obdulia
Patent: WO2012/20215 A1, 2012 ;
Location in patent: Page/Page column 70 ;
WO 2012/020215 A1
反应条件
in ethanol 12 h; Reflux;
参考文献
Copin, Chloe; Henry, Nicolas; Buron, Frederic; Routier, Sylvain
European Journal of Organic Chemistry, 2012 , # 16 p. 3079 - 3083
反应条件
hydrogenchloride; sodium nitrite; copper in water T=20°C; 3 h;
参考文献
ANACOR PHARMACEUTICALS, INC.; GLAXOSMITHKINE LLC; XIA, Yi; ALLEY, Michael, Richard Kevin; ZHOU, Yasheen; SINGH, Rajeshwar; DING, Charles; CAO, Kathy; PLATTNER, Jacob, J.; OU, Ligong; JIA, Guofeng; SARASWAT, Neerja; RAMACHANDRAN, Sreekanth; ZHOU, Ding
Patent: WO2011/17125 A1, 2011 ;
Location in patent: Page/Page column 276 ;
反应条件
1,1-dimethylnitroethane; copper(ll) bromide
参考文献
Xiao, Dong; Palani, Anandan; Sofolarides, Michael; Huang, Ying; Aslanian, Robert; Vaccaro, Henry; Hong, Liwu; McKittrick, Brian; West Jr., Robert E.; Williams, Shirley M.; Wu, Ren-Long; Hwa, Joyce; Sondey, Christopher; Lachowicz, Jean
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 861 - 864
反应条件
in dichloromethane; isopropyl alcohol
参考文献
Kornacker, Michael G.; Mapelli, Claudio; Riexinger, Douglas James
Patent: US2013/289238 A1, 2013 ;
Location in patent: Page/Page column ;
反应条件
in water 20 h; Heating / reflux;
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO)
Patent: WO2009/40552 A2, 2009 ;
Location in patent: Page/Page column 51 ;
WO 2009/040552 A2
参考文献
Herrling; Siegfried
Patent: US4281120 A1, 1981 ;
