1,1'-二甲基-1H,1'H-[2,2']联咪唑合成路线 （共 9 条）
反应条件
1: 2,2'-bi-1H-imidazole With sodium hydride in DMF (N,N-dimethyl-formamide)
T=0°C; 1 h;
2: methyl 4-toluenesulfonate in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 49 h;
参考文献
ROCHE DIAGNOSTICS GMBH; F.HOFFMANN-LA ROCHE AG
Patent: WO2005/26178 A2, 2005 ;
Location in patent: Page/Page column 77-78; Sheet 31 ;
反应条件
sodium 5-methyl-2-pyridonate; copper(l) chloride in para-xylene
T=140°C; 20 h;
参考文献
Zhu, Mingwen; Fujita, Ken-Ichi; Yamaguchi, Ryohei
Chemical Communications, 2011 , vol. 47, # 48 p. 12876 - 12878
反应条件
copper in N,N-dimethyl-formamide
Ullmann coupling; 4 h; Heating;
参考文献
Park, Soon Bong; Alper, Howard
Organic Letters, 2003 , vol. 5, # 18 p. 3209 - 3212
反应条件
copper diacetate in anhydrous xylene
T=140°C; 12 h; regioselective reaction;
参考文献
Li, Yan; Jin, Jun; Qian, Weixing; Bao, Weiliang
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 2 p. 326 - 330
反应条件
1: 2,2'-bi-1H-imidazole With sodium hydroxide in ethanol
Reflux;
2: dimethyl sulfate in ethanol
Reflux;
参考文献
Walker; Douglas; Mac Lean
Canadian Journal of Chemistry, 2009 , vol. 87, # 6 p. 729 - 737
反应条件
pyridine 1-oxide; Pd-Pt/C
T=180 - 190°C; 18 h;
参考文献
Sekine, Toshikazu; Higuchi, Yoshihiro; Yamada, Tomoko; Murakoshi, Isamu
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 1987 - 1989
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; Inert atmosphere;
参考文献
Shan, Guo-Gang; Li, Hai-Bin; Mu, Zhong-Cheng; Zhu, Dong-Xia; Su, Zhong-Min; Liao, Yi
Journal of Organometallic Chemistry, 2012 , vol. 702, p. 27 - 35
反应条件
Pd-Pt/C
T=180 - 190°C; 18 h;
参考文献
Sekine, Toshikazu; Higuchi, Yoshihiro; Yamada, Tomoko; Murakoshi, Isamu
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 1987 - 1989
反应条件
tetrabutylammomium bromide; sodium carbonate in benzene
4 h; Heating;
参考文献
Tjiou, El Mostafa; Fruchier, Alain; Pellegrin, Valdo; Tarrago, Georges
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 893 - 898
