beta-雌二醇 17-丙酸酯合成路线 （共 6 条）
反应条件
potassium carbonate in methanol 1.5 h; Ambient temperature;
参考文献
Shuvalova, S. D.; Men'shova, N. I.; Grinenko, G. S.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 663 - 664
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1107 - 1108
反应条件
1: 80.03 percent / pyridine / 1 h / 105 - 110 °C 2: 99.8 percent / 1percent K2CO3 / methanol / 1.5 h / Ambient temperature View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 17, # 9 p. 663 - 664
Khimiko-Farmatsevticheskii Zhurnal, , vol. 17, # 9 p. 1107 - 1108
反应条件
1: 1.) 18.8percent aq. NaOH, 2.) NaBH4 / 1.) MeOH 2: 80.03 percent / pyridine / 1 h / 105 - 110 °C 3: 99.8 percent / 1percent K2CO3 / methanol / 1.5 h / Ambient temperature View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 17, # 9 p. 663 - 664
Khimiko-Farmatsevticheskii Zhurnal, , vol. 17, # 9 p. 1107 - 1108
参考文献
Yakugaku Zasshi, , vol. 76, p. 847
Chem.Abstr., , p. 1237
参考文献
Helvetica Chimica Acta, , vol. 20, p. 263,268
US2233025 , ;
CH213383 , ;
反应条件
water in methanol T=40°C; pH 9, also reaction in the presence of 2-hydroxypropyl-β-cyclodextrin; Rate constant;
参考文献
Albers; Muller
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 8 p. 756 - 761
