2-氨基-5-甲基-5,6-二氢苯并[d]噻唑-7(4h)-酮合成路线 （共 3 条）
反应条件
1: 5-methyl-cyclohexane-1,3-dione With bromine; sodium acetate; acetic acid
T=15 - 20°C;
2: thiourea T=100°C; 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; VAN DER VEEN, Lars; MC CONNELL, Darryl; SCHNEIDER, Siegfried; GRAUERT, Matthias; SCHOOP, Andreas; WUNBERG, Tobias
Patent: WO2010/122091 A1, 2010 ;
Location in patent: Page/Page column 15 ;
WO 2010/122091 A1
反应条件
sodium acetate in acetic acid
T=100°C; 3 h;
参考文献
GILEAD SCIENCES, INC.; MITCHELL, Michael L.; ROETHLE, Paul A.; XU, Lianhong; YANG, Hong; MCFADDEN, Ryan; BABAOGLU, Kerim
Patent: WO2012/145728 A1, 2012 ;
Location in patent: Page/Page column 125 ;
反应条件
1: bromine; acetic acid / 0.58 h
2: sodium acetate / acetic acid / 3 h / 100 °C
View Scheme
参考文献
GILEAD SCIENCES, INC.; MITCHELL, Michael L.; ROETHLE, Paul A.; XU, Lianhong; YANG, Hong; MCFADDEN, Ryan; BABAOGLU, Kerim
Patent: WO2012/145728 A1, 2012 ;
