N-苯基双(三氟甲烷磺酰)亚胺合成路线 （共 107 条）
反应条件
potassium hexamethylsilazane in tetrahydrofuran; toluene
T=-78°C; Esterification; 4 h;
参考文献
Carreno, M. Carmen; Urbano, Antonio; Di Vitta, Claudio
Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8320 - 8330
反应条件
1: 3-Oxo-pyrrolidine-1-carboxylic acid tert-butyl ester With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.25 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-78 - 20°C; 4 h;
3: p-nitrophenyl boronic acid Further stages;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 152-153 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=0 - 20°C; 1.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/30361 A2, 2007 ;
Location in patent: Page/Page column 44-45 ;
WO 2007/030361 A2
反应条件
caesium carbonate in tetrahydrofuran
T=0°C; 2 h;
参考文献
Cottyn, Betty; Vichard, Dominique; Terrier, Francois; Nioche, Pierre; Raman
Synlett, 2007 , # 8 p. 1203 - 1206
反应条件
potassium carbonate in tetrahydrofuran
T=120°C; 0.1 h; microwave heating;
参考文献
Bengtson, Anna; Hallberg, Anders; Larhed, Mats
Organic Letters, 2002 , vol. 4, # 7 p. 1231 - 1233
反应条件
1: N-Boc-4-oxo-L-proline methyl ester With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.333333 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-78°C; 3 h;
参考文献
PRESIDIO PHARMACEUTICALS, INC.; LI, Leping; ZHONG, Min
Patent: WO2011/156543 A2, 2011 ;
Location in patent: Page/Page column 20 ;
WO 2011/156543 A2
反应条件
1: 2-(methylthio)cyclopentanone With potassium hexamethylsilazane in tetrahydrofuran
T=-78°C; 0.333333 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-78°C; 0.333333 h;
3: With 2,6-dimethylpyridine in dimethyl sulfoxide
T=80°C; 2 h; Further stages.;
参考文献
Hynes Jr., John; Nasser, Talal; Overman, Larry E.; Watson, Donald A.
Organic Letters, 2002 , vol. 4, # 6 p. 929 - 931
参考文献
Mmutlane, Edwin M.; Harris, Joel M.; Padwa, Albert
Journal of Organic Chemistry, 2005 , vol. 70, # 20 p. 8055 - 8063
反应条件
1: 3-Oxo-pyrrolidine-1-carboxylic acid tert-butyl ester With sodium hexamethyldisilazane in tetrahydrofuran
T=-75°C; 0.5 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-75 - 0°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG; BENTZIEN, Joerg, Martin; BOYER, Stephen, James; BURKE, Jennifer; ELDRUP, Anne, Bettina; GUO, Xin; HUBER, John, David; KIRRANE, Thomas, Martin; SOLEYMANZADEH, Fariba; SWINAMER, Alan, David
Patent: WO2010/5783 A1, 2010 ;
Location in patent: Page/Page column 151 ;
WO 2010/005783 A1
反应条件
1: 3-Oxo-pyrrolidine-1-carboxylic acid tert-butyl ester With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.25 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-78 - 20°C; 4 h;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 152 ;
