N-苯基双(三氟甲烷磺酰)亚胺合成路线 （共 107 条）
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78 - 20°C; 14.25 h;
参考文献
SANOFI-AVENTIS
Patent: US2009/176775 A1, 2009 ;
Location in patent: Page/Page column 33-34 ;
反应条件
1: cyclohexenon With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.5 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-78 - 0°C; 2 h;
参考文献
Calvet, Geraldine; Guillot, Regis; Blanchard, Nicolas; Kouklovsky, Cyrille
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 24 p. 4395 - 4401
反应条件
cesium fluoride in ethylene glycol dimethyl ether
T=23°C; 6 h;
参考文献
Mi, Yuan; Schreiber, Juerg V.; Corey
Journal of the American Chemical Society, 2002 , vol. 124, # 38 p. 11290 - 11291
反应条件
potassium hexamethylsilazane
1) DMF, THF, -78 deg C, 4h, 2) 0 deg C, 2h; Yield given. Multistep reaction;
参考文献
Corey; Kigoshi, Hideo
Tetrahedron Letters, 1991 , vol. 32, # 38 p. 5025 - 5028
反应条件
1: 3,3-dimethyl-cyclohexanone With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 2 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-78 - 0°C; 3 h;
3: vinyl-tributylstannane With tetrakis(triphenylphosphine) palladium(0); lithium chloride in tetrahydrofuran
36 h; Reflux;
参考文献
Liu, Weiguo; Zhou, Jinming; Geng, Guoyan; Shi, Qingwen; Sauriol, Francoise; Wu, Jian Hui
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 971 - 975
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/2574 A1, 2005 ;
Location in patent: Page 53 ;
反应条件
lithium diisopropyl amide
1.) DME, HMPA, -65 deg C, 15 min; 2.) DME, HMPA, -70 deg C, 5 min then r.t., 3 h; Yield given. Multistep reaction;
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Watanabe, Shizue; Koike, Hirofumi; Matsuno, Haruko; Matsuda, Kenji; Yamakawa, Koji
Tetrahedron, 1995 , vol. 51, # 34 p. 9327 - 9338
