N-苯基双(三氟甲烷磺酰)亚胺合成路线 （共 107 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Selles; Mueller
Organic Letters, 2004 , vol. 6, # 2 p. 277 - 279
反应条件
potassium hexamethylsilazane in tetrahydrofuran T=-78°C;
参考文献
Fuerstner, Alois; De Souza, Dominic; Turet, Laurent; Fenster, Michael D. B.; Parra-Rapado, Liliana; Wirtz, Conny; Mynott, Richard; Lehmann, Christian W.
Chemistry - A European Journal, 2007 , vol. 13, # 1 p. 115 - 134
反应条件
triethylamine in dichloromethane T=1 - 20°C; 13.33 h;
参考文献
Eisai Co., Ltd.
Patent: US2007/10542 A1, 2007 ;
Location in patent: Page/Page column 74 ;
反应条件
1: 4-oxo-piperidine-1-carboxylic acid 2-(trimethylsilyl)ethyl ester With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 1.66667 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-78°C; 4.75 h;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2004/60884 A1, 2004 ;
Location in patent: Page 23-24 ;
WO 2004/060884 A1
反应条件
1: (tert-Butoxycarbonyl)piperidin-3-one With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.333333 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=0°C; 3 h;
3: With sodium hydrogencarbonate in tetrahydrofuran; water
T=0°C;
参考文献
AMGEN INC.; ALLEN, Jennifer; HORNE, Daniel B.; HU, Essa; KALLER, Matthew R.; MONENSCHEIN, Holger; NGUYEN, Thomas T.; REICHELT, Andreas; RZASA, Robert M.
Patent: WO2011/143495 A1, 2011 ;
Location in patent: Page/Page column 84 ;
WO 2011/143495 A1
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=-78 - 20°C;
参考文献
Huestis, Malcolm P.; Liu, Wendy; Volgraf, Matthew; Purkey, Hans E.; Yu, Christine; Wang, Weiru; Smith, Darin; Vigers, Guy; Dutcher, Darrin; Hunt, Kevin W.; Siu, Michael
Tetrahedron Letters, 2013 , vol. 54, # 43 p. 5802 - 5807
反应条件
1: (tert-Butoxycarbonyl)piperidin-3-one With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.25 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=20°C; 2.5 h;
参考文献
Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; Meegalla, Sanath K.; Rudolph, M. Jonathan; Wall, Mark J.; Wilson, Kenneth J.; Desjarlais, Renee L.; Manthey, Carl L.; Molloy, Christopher J.
Patent: US2008/51402 A1, 2008 ;
Location in patent: Page/Page column 59-60 ;
US 20080051402 A1
反应条件
1: (tert-Butoxycarbonyl)piperidin-3-one With lithium diisopropyl amide in tetrahydrofuran
T=-78 - 20°C;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-78°C;
参考文献
OSI PHARMACEUTICALS, INC.; CHEN, Xin; JIN, Meizhong; KLEINBERG, Andrew; LI, An-hu; MULVIHILL, Mark, J.; STEINIG, Arno, G.; WANG, Jing
Patent: WO2010/59771 A1, 2010 ;
Location in patent: Page/Page column 47 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; Acylation; 8 h;
参考文献
Wentworth; Wentworth Jr.; Mansoor; Janda
Organic letters, 2000 , vol. 2, # 4 p. 477 - 480
反应条件
1: 3,4-dihydronaphthalene-1(2H)-one With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1 h; Inert atmosphere;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=-78 - 20°C; Inert atmosphere;
参考文献
Hon, Yung-Son; Tseng, Tze-Wei; Cheng, Chia-Yi
Chemical Communications, 2009 , # 37 p. 5618 - 5620
