N-苯基双(三氟甲烷磺酰)亚胺合成路线 （共 107 条）
反应条件
1: acetophenone With potassium hexamethylsilazane in tetrahydrofuran; toluene
T=-78°C; 0.666667 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran; toluene
T=-78 - 0°C; 2 h;
参考文献
Shimizu, Ryo; Egami, Hiromichi; Hamashima, Yoshitaka; Sodeoka, Mikiko
Angewandte Chemie - International Edition, 2012 , vol. 51, # 19 p. 4577 - 4580
反应条件
n-butyllithium; lithium diisopropyl amide
1.) THF, HMPA, -78 deg C, 20 min; 2.) THF, HMPA, -78 deg C, 50 min; 3.) THF, HMPA, -83 deg C, 5 min; Yield given. Multistep reaction;
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Watanabe, Shizue; Koike, Hirofumi; Matsuno, Haruko; Matsuda, Kenji; Yamakawa, Koji
Tetrahedron, 1995 , vol. 51, # 34 p. 9327 - 9338
反应条件
lithium diisopropyl amide in ethylene glycol dimethyl ether
1) -78 deg C, 2 hr, 2) 0 deg C, 9 h;
参考文献
Mc Murray, John E.; Scott, William J.
Tetrahedron Letters, 1983 , vol. 24, # 10 p. 979 - 982
反应条件
bromomagnesium diisopropylamide
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Scott, William J.; Crisp, G. T.; Stille, J. K.
Journal of the American Chemical Society, 1984 , vol. 106, # 16 p. 4630 - 4632
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; Acylation; 8 h;
参考文献
Wentworth; Wentworth Jr.; Mansoor; Janda
Organic letters, 2000 , vol. 2, # 4 p. 477 - 480
反应条件
1: 1-(3-bromophenyl)propanone With sodium hydride in tetrahydrofuran
T=0°C;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran
T=0 - 20°C;
参考文献
Wallace, Debra J.; Klauber, David J.; Chen, Cheng-Yi; Volante, Ralph P.
Organic Letters, 2003 , vol. 5, # 24 p. 4749 - 4752
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran
参考文献
Tessier, Pierre E.; Nguyen, Natalie; Clay, Matthew D.; Fallis, Alex G.
Organic Letters, 2005 , vol. 7, # 5 p. 767 - 770
反应条件
1: (4-oxo-cyclohexyl)-carbamic acid tert-butyl ester With potassium hexamethylsilazane in tetrahydrofuran; toluene
T=-70°C; 0.333333 h;
2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran; toluene
T=-70°C; 0.416667 h;
3: With ammonium chloride in tetrahydrofuran; water; toluene
参考文献
Borzilleri, Robert M.; Cornelius, Lyndon A.M.; Schmidt, Robert J.; Schroeder, Gretchen M.; Kim, Kyoung S.
Patent: US2005/245530 A1, 2005 ;
Location in patent: Page/Page column 48 ;
US 20050245530 A1
反应条件
potassium hexamethylsilazane in tetrahydrofuran
T=-78°C; 0.5 h;
参考文献
Kotoku, Naoyuki; Sumii, Yuji; Hayashi, Takeshi; Tamura, Satoru; Kawachi, Takashi; Shiomura, Sho; Arai, Masayoshi; Kobayashi, Motomasa
Medicinal Chemistry letters, 2012 , vol. 3, # 8 p. 673 - 677,5
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=20°C; 2 h;
参考文献
MICROBIA, INC.; MARTINEZ, Eduardo; SCHAIRER, Wayne C.; TALLEY, John J.
Patent: WO2006/124713 A2, 2006 ;
Location in patent: Page/Page column 262-263 ;
