1: sodium carbonate / water; dichloromethane; toluene / 1 h / 20 - 35 °C / |Inert atmosphere; |Large scale 2: sodium tetrahydroborate / methanol; tetrahydrofuran / 2.5 h / 50 °C / |Inert atmosphere; |Reflux; |Large scale 3: sodium bromide; sodium hydrogencarbonate; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite / water; dichloromethane / 0.33 h / 10 °C / |Inert atmosphere; |Large scale 4: sodium tris(acetoxy)borohydride / ethyl acetate / 2 h / 0 - 15 °C / |Inert atmosphere; |Large scale View Scheme

1: 5 palladium on charcoal; hydrogen / methanol / 50 °C / 2250.23 Torr / |Inert atmosphere; |Large scale 2: sodium tris(acetoxy)borohydride / ethyl acetate / 2 h / 0 - 15 °C / |Inert atmosphere; |Large scale View Scheme