ethylenediamine T=50°C; 4 h;

1: 91 percent / K2CO3 / dimethylformamide / 2.5 h / 80 °C 2: 94 percent / ethylenediamine / 4 h / 50 °C View Scheme

1: 47 percent / pyridine / dimethylformamide / 4 h 2: N,N-dimethylaminopyridine / acetonitrile / 3 h / Ambient temperature 3: tributyltin hydride, α,α'-azoisobutyronitrile (AIBN) / toluene / 8 h / 75 °C 4: tetrabutylammonium fluoride / tetrahydrofuran / 0.25 h / Ambient temperature View Scheme

1: N,N-dimethylaminopyridine / acetonitrile / 3 h / Ambient temperature 2: tributyltin hydride, α,α'-azoisobutyronitrile (AIBN) / toluene / 8 h / 75 °C 3: tetrabutylammonium fluoride / tetrahydrofuran / 0.25 h / Ambient temperature View Scheme

1: tributyltin hydride, α,α'-azoisobutyronitrile (AIBN) / toluene / 8 h / 75 °C 2: tetrabutylammonium fluoride / tetrahydrofuran / 0.25 h / Ambient temperature View Scheme

1: pyridine / 24 h / Ambient temperature 2: K2CO3, 18-crown-6-ether / dimethylformamide / 36 h / 40 °C 3: 5N NaOH / ethanol / 0.83 h / Heating 4: TFA / CH2Cl2 / 3 h / Ambient temperature View Scheme

1: K2CO3, 18-crown-6-ether / dimethylformamide / 36 h / 40 °C 2: 5N NaOH / ethanol / 0.83 h / Heating 3: TFA / CH2Cl2 / 3 h / Ambient temperature View Scheme

in methanol T=75°C; 7 h; Irradiationdifferent reaction times, influence of irradiation; Mechanism;

1: 98 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 97 percent / p-toluenesulfonyl chloride, pyridine / 24 h / Heating 3: 55 percent / isoamyl nitrite, CH2I2 / 0.33 h / 100 °C 4: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C 5: NH3 / methanol 6: 70 percent / NH3 / methanol / 12 h / 120 °C 7: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme