3,4-二氢-6-(4,4,5,5-四甲基-1,3,2-二噁硼烷)-1(2h)-异喹啉酮合成路线 (共 3 条)
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in dimethyl sulfoxide
T=90°C; Suzuki Coupling; 5 h; Inert atmosphere;
参考文献
Spicer, Julie A.; Lena, Gersande; Lyons, Dani M.; Huttunen, Kristiina M.; Miller, Christian K.; O'Connor, Patrick D.; Bull, Matthew; Helsby, Nuala; Jamieson, Stephen M. F.; Denny, William A.; Ciccone, Annette; Browne, Kylie A.; Lopez, Jamie A.; Rudd-Schmidt, Jesse; Voskoboinik, Ilia; Trapani, Joseph A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9542 - 9555
反应条件
potassium acetate in 1,4-dioxane; dichloromethane; ethyl acetate
参考文献
Incyte Corporation; Zhuo, Jincong; Xu, Meizhong; Qian, Ding-Quan
Patent: US2014/171405 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: trichlorophosphate; phosphorous pentoxide / 2 h / |Reflux
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 5 h / 90 °C / |Inert atmosphere
View Scheme
参考文献
Spicer, Julie A.; Lena, Gersande; Lyons, Dani M.; Huttunen, Kristiina M.; Miller, Christian K.; O'Connor, Patrick D.; Bull, Matthew; Helsby, Nuala; Jamieson, Stephen M. F.; Denny, William A.; Ciccone, Annette; Browne, Kylie A.; Lopez, Jamie A.; Rudd-Schmidt, Jesse; Voskoboinik, Ilia; Trapani, Joseph A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9542 - 9555