2-(4,4,5,5-四甲基-1,3,2-二氧硼烷)-苯并[b]噻吩合成路线 （共 9 条）
反应条件
1: benzo[b]thiophene With n-butyllithium in diethyl ether; hexane T=-78 - 20°C; 1 h; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in diethyl ether; hexane T=-78 - 20°C; 17 h;
参考文献
Sandee, Albertus J.; Williams, Charlotte K.; Evans, Nicholas R.; Davies, John E.; Boothby, Clare E.; Koehler, Anna; Friend, Richard H.; Holmes, Andrew B.
Journal of the American Chemical Society, 2004 , vol. 126, # 22 p. 7041 - 7048
反应条件
2,2'-bipyridine-4,4'-dicarboxylic acid-iridium complex in 2-methyl cyclohexane T=80°C; 12 h;
参考文献
Tagata, Tsuyoshi; Nishida, Mayumi; Nishida, Atsushi
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 10 p. 1662 - 1666
反应条件
4,4'-di-tert-butyl-2,2'-dipyridyl; bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I) in hexane T=25°C; 2 h;
参考文献
Ishiyama, Tatsuo; Nobuta, Yusuke; Hartwig, John F.; Miyaura, Norio
Chemical Communications, 2003 , # 23 p. 2924 - 2925
反应条件
trifluoroacetic acid in diethyl ether 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 23 p. 5644 - 5654
反应条件
1: AlCl3, aluminium chloride; BCl3*C9H13N / 1,2-dichloro-benzene / 40 h / 80 °C / |Glovebox; |Inert atmosphere 2: triethylamine / 1 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 1 p. 474 - 487
反应条件
triethylamine T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Bagutski, Viktor; Del Grosso, Alessandro; Carrillo, Josue Ayuso; Cade, Ian A.; Helm, Matthew D.; Lawson, James R.; Singleton, Paul J.; Solomon, Sophia A.; Marcelli, Tommaso; Ingleson, Michael J.
Journal of the American Chemical Society, 2013 , vol. 135, # 1 p. 474 - 487
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethanol T=100°C; Suzuki Coupling; 18 h; Inert atmosphere;
参考文献
Goggins, Sean; Rosevere, Eleanor; Bellini, Clement; Allen, Joseph C.; Marsh, Barrie J.; Mahon, Mary F.; Frost, Christopher G.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 1 p. 47 - 52
反应条件
1,10-phenanthroline; lithium hydroxide hydrate; CuTC in dichloromethane
T=45°C; Inert atmosphere;
参考文献
Liu, Tianfei; Shao, Xinxin; Wu, Yaming; Shen, Qilong
Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 540 - 543
反应条件
1: 2,5-dibromo-pyridine With tetrakis(triphenylphosphine) palladium(0); sodium carbonate in tetrahydrofuran
T=75°C;
2: 2-(4',4',5',5'-tetramethyl-1',3',2'-dioxaborolan-2'-yl)benzo[b]thiophene in tetrahydrofuran
T=20°C; 16 h;
参考文献
Sandee, Albertus J.; Williams, Charlotte K.; Evans, Nicholas R.; Davies, John E.; Boothby, Clare E.; Koehler, Anna; Friend, Richard H.; Holmes, Andrew B.
Journal of the American Chemical Society, 2004 , vol. 126, # 22 p. 7041 - 7048
