4-溴-2-(1-甲基乙基)噻唑合成路线 (共 2 条)
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran T=20°C;
参考文献
Gebauer, Julian; Arseniyadis, Stellios; Cossy, Janine
European Journal of Organic Chemistry, 2008 , # 16 p. 2701 - 2704
反应条件
1: isopropyllithium With zinc(II) chloride in tetrahydrofuran; pentane T=-78 - 20°C; 0.5 h; 2: 2,4-dibromo-1,3-thiazole With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran; pentane T=20°C; Negishi cross-coupling; 16 h; Further stages.;
参考文献
Gross, Stefan; Heuser, Stefan; Ammer, Carolin; Heckmann, Golo; Bach, Thorsten
Synthesis, 2011 , # 2 art. no. Z29310SS, p. 199 - 206