5-氯-2-羟基-[1,1-联苯]-3-羧酸合成路线 （共 3 条）
反应条件
1: sulfuric acid; nitric acid; acetic acid / 1 h / 20 °C 2: hydrogen; palladium 10 on activated carbon; triethylamine / methanol / 21 h / 20 °C / 7500.75 Torr / |Autoclave View Scheme
参考文献
ASSIA CHEMICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.; AVDAGIC, Amir; BARAN, Phil, S.
Patent: WO2013/49605 A1, 2013 ;
反应条件
sulfuric acid; nitric acid; acetic acid T=20°C; 1 h;
参考文献
ASSIA CHEMICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.; AVDAGIC, Amir; BARAN, Phil, S.
Patent: WO2013/49605 A1, 2013 ;
Location in patent: Paragraph 0052 ;
反应条件
palladium diacetate; sodium carbonate in water
T=50°C; 4 h; Inert atmosphere;
参考文献
ASSIA CHEMICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.; AVDAGIC, Amir; BARAN, Phil, S.
Patent: WO2013/49605 A1, 2013 ;
Location in patent: Paragraph 0050 ;
