3’-氨基-2’-羟基-[1,1’-联苯]-3-甲酸合成路线 （共 7 条）
反应条件
palladium 10 on activated carbon; hydrogen; triethylamine in methanol T=20°C; P=7500.75 Torr; 21 h; Autoclave;
参考文献
ASSIA CHEMICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.; AVDAGIC, Amir; BARAN, Phil, S.
Patent: WO2013/49605 A1, 2013 ;
Location in patent: Paragraph 0058 ;
反应条件
hydrogen; 5 Pd(II)/C(eggshell) in methanol T=20°C; 8 h;
参考文献
PLIVA HRVATSKA D.O.O.
Patent: US2010/256212 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
1: sodium carbonate; palladium diacetate / water / 4 h / 50 °C / |Inert atmosphere 2: sulfuric acid; nitric acid; acetic acid / 1 h / 20 °C 3: hydrogen; palladium 10 on activated carbon; triethylamine / methanol / 21 h / 20 °C / 7500.75 Torr / |Autoclave View Scheme
反应条件
1: sodium carbonate; palladium diacetate / water / 4 h / 50 °C / |Inert atmosphere 2: sulfuric acid; nitric acid; acetic acid / 1 h / 20 °C 3: hydrogen; palladium 10 on activated carbon; triethylamine / methanol / 21 h / 20 °C / 7500.75 Torr / |Autoclave View Scheme
反应条件
1: sulfuric acid; nitric acid; acetic acid / 1 h / 20 °C 2: hydrogen; palladium 10 on activated carbon; triethylamine / methanol / 21 h / 20 °C / 7500.75 Torr / |Autoclave View Scheme
反应条件
1: acetic acid; bromine / 3.5 h / 5 - 20 °C 2: sodium carbonate; palladium diacetate / water / 3.5 h / 50 °C / |Inert atmosphere 3: hydrogen; palladium 10 on activated carbon; triethylamine / methanol / 21 h / 20 °C / 7500.75 Torr / |Autoclave View Scheme
反应条件
1: sodium carbonate; palladium diacetate / water / 3.5 h / 50 °C / |Inert atmosphere 2: hydrogen; palladium 10 on activated carbon; triethylamine / methanol / 21 h / 20 °C / 7500.75 Torr / |Autoclave View Scheme
