2,4-二甲基吡啶-3-甲酸乙酯合成路线 （共 17 条）
反应条件
1: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane; hexane T=70°C; 8 h; 2: With methanol in 1,4-dioxane; hexane
参考文献
WO2010/132999 A1, ;
Page/Page column 211 ;
参考文献
Hooff,H. J. G. van; Lier, P. M. van; Bastiaansen, L. A. M.; Buck, H. M.
Recueil: Journal of the Royal Netherlands Chemical Society, 1982 , vol. 101, # 5 p. 191 - 192
反应条件
1: piperidine / ethanol / 3 h / Heating 2: 1 N aq. (NH4)2Ce(NO3)6 / acetone / 0.33 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 9 p. 1841 - 1849
参考文献
Chemische Berichte, , vol. 18, p. 2022
参考文献
Sakaki, Shigeyoshi; Ishikura, Hiroyuki; Kuraki, Ko-ichi; Tanaka, Ko-jyoh; Satoh, Takashi; et al.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1997 , # 11 p. 1815 - 1820
参考文献
Doklady Akademii Nauk SSSR, , vol. 79, p. 609,611
Chem.Abstr., , p. 15894
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
Location in patent: Page/Page column 40 ;
WO 2013/019621 A1
参考文献
Merck and Co., Inc.
Patent: US5726172 A1, 1998 ;
US 5726172 A
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C 2: thionyl chloride / dichloromethane / 0.5 h / 0 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
WO 2013/019621 A1
反应条件
1: With sodium hydroxide; water in ethanol T=20°C; 24 h; 2: With hydrogenchloride in methanol; ethanol; water T=0°C; pH=7;
参考文献
VALEANT PHARMACEUTICALS INTERNATIONAL
Patent: US2008/318979 A1, 2008 ;
Location in patent: Page/Page column 19-20 ;
US 20080318979 A1
