2-氯-3-羟基-4-甲氧基苯甲醛合成路线 （共 21 条）
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 3: 97 percent / 12N aq. HCl 4: 96 percent / dimethylsulfoxide / 1.25 h 5: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 6: 19 percent / 2.5 h / Heating 7: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C 8: 95 percent / BBr3 / CH2Cl2 / 3 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 3: 97 percent / 12N aq. HCl 4: 96 percent / dimethylsulfoxide / 1.25 h 5: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 6: 19 percent / 2.5 h / Heating View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: BBr3 3: ZnI2 4: LiAlH4 5: H2 / Pd/C View Scheme
参考文献
Squier; Van der Schyf; Oliver; Venter
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 3 p. 457 - 460
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
3: 97 percent / 12N aq. HCl
4: 96 percent / dimethylsulfoxide / 1.25 h
5: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
6: K2CO3 / dimethylformamide / 2 h / 110 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
3: 97 percent / 12N aq. HCl
4: 96 percent / dimethylsulfoxide / 1.25 h
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
3: 97 percent / 12N aq. HCl
4: 96 percent / dimethylsulfoxide / 1.25 h
5: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
6: 37 percent / 2.5 h / Heating
7: TFA, 36 N aq. H2SO4 / 3.5 h / 25 °C
8: BBr3 / CH2Cl2 / 3 h / 25 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: selenium(IV) oxide; dihydrogen peroxide / dichloromethane; water / 48 h / 20 °C
2: hydrogenchloride; methanol / 0.5 h / 20 °C
3: methanesulfonic acid; tin(IV) chloride / 6 h / 40 °C
View Scheme
参考文献
Tsybulsky, Dmitry A.; Kvach, Maksim V.; Stepanova, Irina A.; Korshun, Vladimir A.; Shmanai, Vadim V.
Journal of Organic Chemistry, 2012 , vol. 77, # 2 p. 977 - 984
反应条件
1: selenium(IV) oxide; dihydrogen peroxide / dichloromethane; water / 48 h / 20 °C
2: hydrogenchloride; methanol / 0.5 h / 20 °C
3: methanesulfonic acid; tin(IV) chloride / 6 h / 40 °C
View Scheme
参考文献
Tsybulsky, Dmitry A.; Kvach, Maksim V.; Stepanova, Irina A.; Korshun, Vladimir A.; Shmanai, Vadim V.
Journal of Organic Chemistry, 2012 , vol. 77, # 2 p. 977 - 984
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
3: 97 percent / 12N aq. HCl
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
