2,3-二甲基-4-硝基吡啶-N-氧化物合成路线 （共 41 条）
反应条件
1: in ethanol T=65°C; Large scale reaction; 2: With sodium hydroxide in ethanol; water; toluene pH=7.5 - 8.5; Large scale reaction;
参考文献
Organic Process Research and Development, , vol. 14, # 3 p. 562 - 567
反应条件
1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C 2: 5 h / 120 °C 3: NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
1: 37 percent / CH2Cl2 / 12 h / Heating 2: 74 percent / triethylamine / acetonitrile / 12 h / 20 °C View Scheme
参考文献
Radl, Stanislav; Klecan, Ondrej; Havlicek, Jaroslav
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1447 - 1453
反应条件
Multistep reaction. Further byproducts given;
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
1: 94 percent / H2, gl. AcOH / 10percent Pd/C / 12 h / 60 °C / 2585.7 Torr 2: 60 percent / Na2CO3 / acetone / 3 h / Ambient temperature 3: 62 percent / lithium aluminum hydride / tetrahydrofuran / 18 h / Ambient temperature 4: 18 percent / H2SO4, fuming HNO3 / 3 h / 110 °C 5: H2 / 10percent Pd/C / ethanol / 18 h / 2585.7 Torr / Ambient temperature 6: ethanol / 18 h / 110 °C View Scheme
参考文献
Tanga; Bupp; Tochimoto
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 717 - 727
反应条件
1.1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C 2.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 2.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 3.1: 5 h / 120 °C 4.1: NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: With phosphorus trichoride in dichloromethane T=-20 - 15°C; 1 h; 2: With sodium hydroxide; water in dichloromethane T=-78°C;
参考文献
YUHAN CORPORATION; JANG, Sun-Young
Patent: WO2006/38773 A1, 2006 ;
Location in patent: Page/Page column 54 ;
反应条件
1.1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C 2.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 2.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 3.1: 5 h / 120 °C 4.1: NaOH / H2O / 1 h / 25 °C 5.1: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C 6.1: 88 percent / NaOH / H2O / 3 h / 25 °C View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1.1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C 2.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 2.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 3.1: 5 h / 120 °C View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1.1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C 2.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 2.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 3.1: 5 h / 120 °C 4.1: NaOH / H2O / 1 h / 25 °C 5.1: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C 6.1: 88 percent / NaOH / H2O / 3 h / 25 °C 7.1: 57 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / -15 - -10 °C View Scheme
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
