2,3-二甲基-4-硝基吡啶-N-氧化物合成路线 （共 41 条）
反应条件
Multistep reaction. Further byproducts given;
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
反应条件
1: 75 percent / phosphorus oxychloride / CH2Cl2 / 20 °C 2: 52 percent / CH2Cl2 / 12 h / Heating 3: 69 percent / triethylamine / acetonitrile / 18 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453
反应条件
1: 94 percent / tert-BuOK / 42 h / 50 - 60 °C 2: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h 3: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 10 p. 2853 - 2858
反应条件
potassium tert-butylate T=50 - 60°C; 42 h;
参考文献
Kubo; Oda; Kaneko; Satoh; Nohara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2853 - 2858
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
2,2,2-trifluoroethanol T=50°C; 12 h;
参考文献
Ma, Chao; Wu, Anhui; Wu, Yongqi; Ren, Xuhong; Cheng, Maosheng
Archiv der Pharmazie, 2013 , vol. 346, # 12 p. 891 - 900
反应条件
1: 94 percent / tert-BuOK / 42 h / 50 - 60 °C 2: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h View Scheme
参考文献
Ma, Chao; Wu, Anhui; Wu, Yongqi; Ren, Xuhong; Cheng, Maosheng
Archiv der Pharmazie, 2013 , vol. 346, # 12 p. 891 - 900
反应条件
1: 75 percent / phosphorus oxychloride / CH2Cl2 / 20 °C 2: 52 percent / CH2Cl2 / 12 h / Heating 3: 69 percent / triethylamine / acetonitrile / 18 h / 20 °C 4: 29.5 percent / potassium hydroxide / dimethylsulfoxide / 336 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453
反应条件
1: 75 percent / phosphorus oxychloride / CH2Cl2 / 20 °C 2: 52 percent / CH2Cl2 / 12 h / Heating 3: 69 percent / triethylamine / acetonitrile / 18 h / 20 °C 4: 29.5 percent / potassium hydroxide / dimethylsulfoxide / 336 h / 20 °C 5: 33.5 percent / aq. sodium carbonate; peracetic acid / CH2Cl2 / 20 h / 20 °C View Scheme
参考文献
Radl, Stanislav; Klecan, Ondrej; Havlicek, Jaroslav
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1447 - 1453
反应条件
Multistep reaction. Further byproducts given;
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
